Q:
How to make annotations or signature in PDF visible by other programs?
-- How to make annotations visible after printing or sending PDF via email?
A:

To keep all the changes in PDF file, save your file as flattened copy. Flattening is a process of applying all annotations, form data and markups to a PDF. No changes can be made to annotations or form data after the flattening. To save your documents as flattened copy please click File on main menu and choose to "Save as Flattened PDF" or click Share -> Flattened Copy and then save the annotated file as Flattened PDF.

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